I have dry, dehydrated, mature skin & reside in south Florida where it’s hot and humid all year. The Summers are especially brutal on my skin. I use Cream Dermo-RL with 4 drops of Serum TEWL & this leaves my skin hydrated & supple. I just started adding Cream Placenta with this & Wow! Instant plump skin. I do use Colostrum, Serum A-Glyca & Matriciel Visage underneath & top off with Y’all 02. Of course I start with 1970 P V. I did notice my dry fine lines on my forehead were diminishing with the Dermo RL samples & I ordered the regular size.